Differential dissociation of G protein heterotrimers
نویسندگان
چکیده
منابع مشابه
Some G protein heterotrimers physically dissociate in living cells.
Heterotrimeric G proteins mediate physiological processes ranging from phototransduction to cell migration. In the accepted model of G protein signaling, Galphabetagamma heterotrimers physically dissociate after activation, liberating free Galpha subunits and Gbetagamma dimers. This model is supported by evidence obtained in vitro with purified proteins, but its relevance in vivo has been quest...
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The concept that a guanosine triphosphate (GTP) binding protein (or G protein) is a transducer of receptor-to-effector signal transduction was formulated in the 1970s for hormonedependent adenylyl cyclase. It has been shown that binding of the hormone to the receptor triggers exchange of guanosine diphosphate (GDP) for GTP on the G protein, thereby converting the G protein from the inactive con...
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G protein βγ subunits play essential roles in regulating cellular signaling cascades, yet little is known about their distribution in tissues or their subcellular localization. While previous studies have suggested specific isoforms may exhibit a wide range of distributions throughout the central nervous system, a thorough investigation of the expression patterns of both Gβ and Gγ isoforms with...
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A growing body of evidence suggests that GPCRs exist and function as dimers or higher oligomers. The evidence for GPCR dimerization comes from biochemical, biophysical and functional studies. In addition, researchers have shown the occurrence of heterodimerization between different members of the GPCR family. Two receptors can interact with each other to make a dimer through their extracellular...
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ژورنال
عنوان ژورنال: The Journal of Physiology
سال: 2008
ISSN: 0022-3751
DOI: 10.1113/jphysiol.2008.153965